| Optiscan Imaging Ltd

Brain

Intraoperative Confocal Laser Endomicroscopy: Prospective in Vivo Feasibility Study of a Clinical-Grade System for Brain Tumors." Journal of Neurosurgery (01 Jul. 2022 2022): 1-11

Abramov, Irakliy, Marian T. Park, Evgenii Belykh, Alexander B. Dru, Yuan Xu, Timothy C. Gooldy, Lea Scherschinski, S. Harrison Farber, Andrew S. Little, Randall W. Porter, Kris A. Smith, Michael T. Lawton, Jennifer M. Eschbacher, and Mark C. Preul.

Real-Time Intraoperative Surgical Telepathology Using Confocal Laser Endomicroscopy. Neurosurgical Focus 52, no. 6 (01 Jun. 2022 2022): E9

Abramov, Irakliy, Marian T. Park, Timothy C. Gooldy, Yuan Xu, Michael T. Lawton, Andrew S. Little, Randall W. Porter, Kris A. Smith, Jennifer M. Eschbacher, and Mark C. Preul.

Progress in Confocal Laser Endomicroscopy for Neurosurgery and Technical Nuances for Brain Tumor Imaging with Fluorescein." Technology Report, Frontiers in Oncology 9, no. 554 (2019-July-03 2019)

Belykh, Evgenii, Eric J. Miller, Alessandro Carotenuto, Arpan A. Patel, Claudio Cavallo, Nikolay L. Martirosyan, Debbie R. Healey, Vadim A. Byvaltsev, Adrienne C. Scheck, Michael T. Lawton, Jennifer M. Eschbacher, Peter Nakaji, and Mark C. Preul.

Confocal Laser Microscopy in Neurosurgery: State of the Art of Actual Clinical Applications." Journal of Clinical Medicine 10, no. 9 (2021): 2035

Restelli, Francesco, Bianca Pollo, Ignazio Gaspare Vetrano, Samuele Cabras, Morgan Broggi, Marco Schiariti, Jacopo Falco, Camilla de Laurentis, Gabriella Raccuia, Paolo Ferroli, and Francesco Acerbi.

Characterization of Ex Vivo and in Vivo Intraoperative Neurosurgical Confocal Laser Endomicroscopy Imaging." Original Research, Frontiers in Oncology 12 (2022-August-24 2022)

Xu, Yuan, Irakliy Abramov, Evgenii Belykh, Giancarlo Mignucci-Jiménez, Marian T. Park, Jennifer M. Eschbacher, and Mark C. Preul.

General Surgery

Near-infrared confocal imaging during mini-laparoscopy: a novel rigid endomicroscope with increased imaging plane depth', J Hepatol, 53: 84-90

Goetz, M., I. Deris, M. Vieth, E. Murr, A. Hoffman, P. Delaney, P. R. Galle, M. F. Neurath, and R. Kiesslich. 2010.

In vivo confocal laser endomicroscopy of the human liver: a novel method for assessing liver microarchitecture in real time', Endoscopy, 40: 554-62

Goetz, M., R. Kiesslich, H. P. Dienes, U. Drebber, E. Murr, A. Hoffman, S. Kanzler, P. R. Galle, P. Delaney, and M. F. Neurath. 2008.

A Pilot Study of the Feasibility of Confocal Endomicroscopy for Examination of the Human Airway', Journal of Bronchology & Interventional Pulmonology, 17: 126-30

Musani, A. I. M., M. M. Sims, C. M. Sareli, W. R. Russell, W. J. P. McLaren, P. M. B. H. Delaney, L. A. M. Litzky and R. A. J. M. Panettieri. 2010.

Cervical

Confocal endomicroscopy: A novel imaging technique for in vivo histology of cervical intraepithelial neoplasia', Expert Review of Medical Devices, 4: 863-71

Tan, J., P. Delaney, and W. J. McLaren. 2007.

Detection of cervical intraepithelial neoplasia in vivo using confocal endomicroscopy', BJOG: An International Journal of Obstetrics and Gynaecology, 116: 1663-70

Tan, J., M. A. Quinn, J. M. Pyman, P. M. Delaney, and W. J. McLaren. 2009.

Gastrointestinal

Prospective, double-blind diagnostic multicentre study of confocal laser endomicroscopy for wheat sensitivity in patients with irritable bowel syndrome', Gut: gutjnl-2021-325181

Bojarski, Christian, Paul Tangermann, Christian Barmeyer, Juliane Buchkremer, Ralf Kiesslich, Mark Ellrichmann, Stefan Schreiber, Carsten Schmidt, Andreas Stallmach, Robert Roehle, Christoph Loddenkemper, Severin Daum, Britta Siegmund, Michael Schumann, and Reiner Ullrich. 2021.

In vivo endomicroscopy improves detection of Barrett's esophagus–related neoplasia: a multicenter international randomized controlled trial (with video)', Gastrointestinal Endoscopy, 79: 211-21

Canto, Marcia Irene, Sharmila Anandasabapathy, William Brugge, Gary W. Falk, Kerry B. Dunbar, Zhe Zhang, Kevin Woods, Jose Antonio Almario, Ursula Schell, John Goldblum, Anirban Maitra, Elizabeth Montgomery, and Ralf Kiesslich. 2014.

In Vivo Confocal Endomicroscopy in the Diagnosis and Evaluation of Celiac Disease', Gastroenterology, 135: 1870-76

Leong, Rupert W. L., Nam Q. Nguyen, Christopher G. Meredith, Sam Al–Sohaily, Darko Kukic, Peter M. Delaney, Elise R. Murr, Jim Yong, Neil D. Merrett, and Andrew V. Biankin. 2008.

'Diagnostic value of confocal laser endomicroscopy for gastric superficial cancerous lesions', Gut, 60: 299.
Li, Wen-Bo, Xiu-Li Zuo, Chang-Qing Li, Fang Zuo, Xiao-Meng Gu, Tao Yu, Chuan-Lian Chu, Ting-Guo Zhang, and Yan-Qing Li. 2011.

Mechanisms of Epithelial Cell Shedding in the Mammalian Intestine and Maintenance of Barrier Function', Annals of the New York Academy of Sciences, 1165: 135-42

Watson, Alastair J.M., Carrie A. Duckworth, Yanfang Guan, and Marshall H. Montrose. 2009.

Cell viability

Fluorescence-Based Tracing of Transplanted Intestinal Epithelial Cells Using Confocal Laser Endomicroscopy." journal article, Stem Cell Research & Therapy 10, no. 1 (May 27 2019): 148

Jensen, Jeffrey M. Karp, and Ole Haagen Nielsen.

In Vivo Real-Time Imaging of the Liver with Confocal Endomicroscopy Permits Visualization of the Temporospatial Patterns of Hepatocyte Apoptosis." American Journal of Physiology - Gastrointestinal and Liver Physiology 301, no. 5 (2011): G764-G72

Goetz, Martin, Jacqueline V. Ansems, Peter R. Galle, Marcus Schuchmann, and Ralf Kiesslich.

Protein Kinase C Delta Null Mice Exhibit Structural Alterations in Articular Surface, Intra-Articular and Subchondral Compartments." journal article, Arthritis Research and Therapy 17, no. 1 (August 17 2015): 210

Yang, Xiaohong, Dian Teguh, Jian-Ping Wu, Bo He, Thomas Brett Kirk, Shengnan Qin, Siming Li, Honghui Chen, Wei Xue, Benjamin Ng, Shek Man Chim, Jennifer Tickner, Jiake %J Arthritis Research Xu, and Therapy.

Live fluorescent or antibody labelling

Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery. Molecular Imaging and Biology

Belykh, E., Jubran, J. H., George, L. L., Bardonova, L., Healey, D. R., Georges, J. F., . . . Preul, M. C. (2021).

In vivo intravital endoscopic confocal fluorescence microscopy of normal and acutely injured rat lungs. Laboratory Investigation, 90(6), 824-834

Chagnon, F., Fournier, C., Charette, P. G., Moleski, L., Payet, M. D., Dobbs, L. G., & Lesur, O. (2010).

Bioinspired Large Stokes Shift Small Molecular Dyes for Biomedical Fluorescence Imaging." Science Advances 8, no. 32 (2022): eabo3289

Chen, Hao, Lingjun Liu, Kun Qian, Hailong Liu, Zhiming Wang, Feng Gao, Chunrong Qu, Wenhao Dai, Daizong Lin, Kaixian Chen, Hong Liu, and Zhen Cheng.

Assessment of nerve ultrastructure by fibre-optic confocal microscopy. 17(8), 444-448

Cushway, T. R., Lanzetta, M., Cox, G., Trickett, R., & Owen, E. R. (1996).

In vivo visualization of GL261-luc2 mouse glioma cells by use of Alexa Fluor–labeled TRP-2 antibodies. Neurosurgical Focus, 36(2), E12

Kathryn E. Fenton, Nikolay L. Martirosyan, Mohammed G. Abdelwahab, Stephen W. Coons, Mark C. Preul, & Adrienne C. Scheck. (2014).

Handheld confocal laser endomicroscopic imaging utilizing tumor-specific fluorescent labeling to identify experimental glioma cells in vivo. Surgical Neurology International, 7(Suppl 40), S995-S1003

Martirosyan, N. L., Georges, J., Kalani, M. Y. S., Nakaji, P., Spetzler, R. F., Feuerstein, B. G., & Preul, M. C. (2016).

In vivo fibre optic confocal imaging of microvasculature and nerves in the rat vas deferens and colon. 192(4), 489-495

PAPWORTH, G. D., DELANEY, P. M., BUSSAU, L. J., VO, L. T., & KING, R. G. (1998).

Intraoperative surgery and tumour margin delineation

Handheld confocal laser endomicroscopic imaging utilizing tumor-specific fluorescent labeling to identify experimental glioma cells in vivo', Surgical Neurology International, 7: S995-S1003

Martirosyan, Nikolay L., Joseph Georges, M. Yashar S. Kalani, Peter Nakaji, Robert F. Spetzler, Burt G. Feuerstein, and Mark C. Preul. 2016.

In vivo confocal laser laparoscopy allows real time subsurface microscopy in animal models of liver disease', J Hepatol, 48: 91-7

Goetz, M., M. Vieth, S. Kanzler, P. R. Galle, P. Delaney, M. F. Neurath, and R. Kiesslich. 2008.

Fluorescence-guided resection of tumors in mouse models of oral cancer', Scientific Reports, 10: 11175

Demétrio de Souza França, Paula, Navjot Guru, Sheryl Roberts, Susanne Kossatz, Christian Mason, Marcio Abrahão, Ronald A. Ghossein, Snehal G. Patel, and Thomas Reiner. 2020.

Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers', Nature Biomedical Engineering, 4: 272-85

Kossatz, Susanne, Giacomo Pirovano, Paula Demétrio De Souza França, Arianna L. Strome, Sumsum P. Sunny, Daniella Karassawa Zanoni, Audrey Mauguen, Brandon Carney, Christian Brand, Veer Shah, Ravindra D. Ramanajinappa, Naveen Hedne, Praveen Birur, Smita Sihag, Ronald A. Ghossein, Mithat Gönen, Marshall Strome, Amritha Suresh, Daniela Molena, Ian Ganly, Moni A. Kuriakose, Snehal G. Patel, and Thomas Reiner. 2020.

Blood vessel, perfusion, and barrier function

Dynamic in vivo Imaging of Microvasculature and Perfusion by Miniaturized Confocal Laser Microscopy', European Surgical Research, 41: 290-97

Goetz, M., S. Thomas, A. Heimann, P. Delaney, C. Schneider, M. Relle, A. Schwarting, P. R. Galle, O. Kempski, M. F. Neurath, and R. Kiesslich. 2008.

Live microflora imaging

In Vivo Histologically Equivalent Evaluation of Gastric Mucosal Topologic Morphology in Dogs By using Confocal Endomicroscopy', Journal of Veterinary Internal Medicine, 28: 799-808

Sharman, M.J., B. Bacci, T. Whittem, and C.S. Mansfield. 2014.

Comparison of in vivo confocal endomicroscopy with other diagnostic modalities to detect intracellular helicobacters', The Veterinary Journal, 213: 78-83

Sharman, M., B. Bacci, K. Simpson, and C. Mansfield. 2016.

Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo', Gut, 60: 26-33

Moussata, Driffa, Martin Goetz, Annabel Gloeckner, Marcus Kerner, Barry Campbell, Arthur Hoffman, Stephan Biesterfeld, Bernard Flourie, Jean-Christophe Saurin, Peter R. Galle, Markus F. Neurath, Alastair J. M. Watson, and Ralf Kiesslich. 2011.

Nano particle and drug delivery

Preparation, in vitro and in vivo evaluation of mPEG-PLGA nanoparticles co-loaded with syringopicroside and hydroxytyrosol', Journal of Materials Science: Materials in Medicine, 27: 24

Guan, Qingxia, Shuang Sun, Xiuyan Li, Shaowa Lv, Ting Xu, Jialin Sun, Wenjing Feng, Liang Zhang, and Yongji Li. 2015.

Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging', Science Advances, 8: eabo3289

Chen, Hao, Lingjun Liu, Kun Qian, Hailong Liu, Zhiming Wang, Feng Gao, Chunrong Qu, Wenhao Dai, Daizong Lin, Kaixian Chen, Hong Liu, and Zhen Cheng. 2022.

Virus surface-inspired ligand-switchable nanoparticles enable sequential drug delivery for improved oral insulin therapy." In.: Research Square

Yang, Tiantian, Aohua Wang, Di Nie, Weiwei Fan, Xiaohe Jiang, Miaorong Yu, Shiyan Guo, Chunliu Zhu, Gang Wei, and Yong Gan. 2022.

Fluorescein- and EGFR-Antibody Conjugated Silica Nanoparticles for Enhancement of Real-time Tumor Border Definition Using Confocal Laser Endomicroscopy in Squamous Cell Carcinoma of the Head and Neck', Nanomaterials, 9

Watermann, Anna, Rita Gieringer, Anna-Maria Bauer, Sven Kurch, Ralf Kiesslich, Wolfgang Tremel, Jan Gosepath, and Juergen Brieger. 2019.

Proof of concept in live models

Identification of Epithelial Gaps in Human Small and Large Intestine by Confocal Endomicroscopy', Gastroenterology, 133: 1769-78.

Kiesslich, Ralf, Martin Goetz, Elizabeth M. Angus, Qiuping Hu, Yanfang Guan, Chris Potten, Terry Allen, Markus F. Neurath, Noah F. Shroyer, Marshall H. Montrose, and Alastair J. M. Watson. 2007.

In vivo intravital endoscopic confocal fluorescence microscopy of normal and acutely injured rat lungs', Laboratory Investigation, 90: 824-34.

Chagnon, Frederic, Clement Fournier, Paul G. Charette, Luc Moleski, Marcel D. Payet, Leland G. Dobbs, and Olivier Lesur. 2010.