Left: Normal
Middle: Pre-cancer
Right: Cancer

Optiscan technology captures single-cell detail of oral mucosa in real time without having to do a biopsy. Scale bar = 100µm

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Tumour island surrounded by leaky blood vessels in live rat brain. The tumour is a Glioblastoma which is highly infiltrative and causes hemorrhage. The contrast agent used here is intravenous fluorescein.

Courtesy of researchers in Barrow Neurological Institute, Phoenix, Arizona, USA

Scale bar = 100µm

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Left: Healthy body wall

Right: Body wall metastases

A comparison between normal body wall (Left) and body wall metastasis (Right) in a rat pancreatic cancer model. Imaged with Optiscan’s first generation endomicroscope, the FIVE1. 0.05% Acriflavine was used as contrast agent. Scale bar = 100µm

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Helicobacter in dog stomach.

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Contrast agent:

Lung endothelial cell nuclei: acridine orange, 0.05% i.v. (single arrow)

Plasma: FITC-Dextran 70kDa, i.v. (double arrow)

Distal epithelial membranes: FITC-R.Communis lectin (triple arrow)

Scale bar = 100µm

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Left: 250µm Z-stack of zebrafish blood vessel endothelium expressing GFP.

Right: Maximum brightness projection

Scale bar = 100µm

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