Left: Normal
Middle: Pre-cancer
Right: Cancer
Optiscan technology captures single-cell detail of oral mucosa in real time without having to do a biopsy. Scale bar = 100µm
Tumour island surrounded by leaky blood vessels in live rat brain. The tumour is a Glioblastoma which is highly infiltrative and causes hemorrhage. The contrast agent used here is intravenous fluorescein.
Courtesy of researchers in Barrow Neurological Institute, Phoenix, Arizona, USA
Scale bar = 100µm
Left: Healthy body wall
Right: Body wall metastases
A comparison between normal body wall (Left) and body wall metastasis (Right) in a rat pancreatic cancer model. Imaged with Optiscan’s first generation endomicroscope, the FIVE1. 0.05% Acriflavine was used as contrast agent. Scale bar = 100µm
Helicobacter in dog stomach.
Contrast agent:
Lung endothelial cell nuclei: acridine orange, 0.05% i.v. (single arrow)
Plasma: FITC-Dextran 70kDa, i.v. (double arrow)
Distal epithelial membranes: FITC-R.Communis lectin (triple arrow)
Scale bar = 100µm
Left: 250µm Z-stack of zebrafish blood vessel endothelium expressing GFP.
Right: Maximum brightness projection
Scale bar = 100µm