Oral

A phase I study of a PARP1-targeted topical fluorophore for the detection of oral cancer', European Journal of Nuclear Medicine and Molecular Imaging
Demétrio de Souza França, Paula, Susanne Kossatz, Christian Brand, Daniella Karassawa Zanoni, Sheryl Roberts, Navjot Guru, Dauren Adilbay, Audrey Mauguen, Cristina Valero Mayor, Wolfgang A. Weber, Heiko Schöder, Ronald A. Ghossein, Ian Ganly, Snehal G. Patel, and Thomas Reiner. 2021. 

Confocal endomicroscopy: a novel application for imaging of oral and oropharyngeal mucosa in human', European Archives of Oto-Rhino-Laryngology, 267: 443-48
Haxel, Boris Rainer, Martin Goetz, Ralf Kiesslich, and Jan Gosepath. 2010. 

Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers', Nature Biomedical Engineering, 4: 272-85
Kossatz, Susanne, Giacomo Pirovano, Paula Demétrio De Souza França, Arianna L. Strome, Sumsum P. Sunny, Daniella Karassawa Zanoni, Audrey Mauguen, Brandon Carney, Christian Brand, Veer Shah, Ravindra D. Ramanajinappa, Naveen Hedne, Praveen Birur, Smita Sihag, Ronald A. Ghossein, Mithat Gönen, Marshall Strome, Amritha Suresh, Daniela Molena, Ian Ganly, Moni A. Kuriakose, Snehal G. Patel, and Thomas Reiner. 2020. 

Systematic Intraoperative Application of Confocal Endomicroscopy for Early Detection and Resection of Squamous Cell Carcinoma of the Head and Neck: A Preliminary ReportIntraoperative Confocal Endomicroscopy for HNSCC', JAMA Otolaryngology–Head & Neck Surgery, 138: 404-11
Pogorzelski, Benjamin, Uli Hanenkamp, Martin Goetz, Ralf Kiesslich, and Jan Gosepath. 2012. 

Confocal fluorescence endomicroscopic imaging of the tongue (SPIE)
Zheng, Wei, Malini Olivo, K. W. Kho, Patricia Thong, Martin Harris, and Khee Chee Soo. 2005. 

November 12th, 2022 by Optiscan
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Brain

Intraoperative Confocal Laser Endomicroscopy: Prospective in Vivo Feasibility Study of a Clinical-Grade System for Brain Tumors." Journal of Neurosurgery  (01 Jul. 2022 2022): 1-11
Abramov, Irakliy, Marian T. Park, Evgenii Belykh, Alexander B. Dru, Yuan Xu, Timothy C. Gooldy, Lea Scherschinski, S. Harrison Farber, Andrew S. Little, Randall W. Porter, Kris A. Smith, Michael T. Lawton, Jennifer M. Eschbacher, and Mark C. Preul. 

Real-Time Intraoperative Surgical Telepathology Using Confocal Laser Endomicroscopy. Neurosurgical Focus 52, no. 6 (01 Jun. 2022 2022): E9
Abramov, Irakliy, Marian T. Park, Timothy C. Gooldy, Yuan Xu, Michael T. Lawton, Andrew S. Little, Randall W. Porter, Kris A. Smith, Jennifer M. Eschbacher, and Mark C. Preul. 

Progress in Confocal Laser Endomicroscopy for Neurosurgery and Technical Nuances for Brain Tumor Imaging with Fluorescein." Technology Report, Frontiers in Oncology 9, no. 554 (2019-July-03 2019)
Belykh, Evgenii, Eric J. Miller, Alessandro Carotenuto, Arpan A. Patel, Claudio Cavallo, Nikolay L. Martirosyan, Debbie R. Healey, Vadim A. Byvaltsev, Adrienne C. Scheck, Michael T. Lawton, Jennifer M. Eschbacher, Peter Nakaji, and Mark C. Preul. 

Confocal Laser Microscopy in Neurosurgery: State of the Art of Actual Clinical Applications." Journal of Clinical Medicine 10, no. 9 (2021): 2035
Restelli, Francesco, Bianca Pollo, Ignazio Gaspare Vetrano, Samuele Cabras, Morgan Broggi, Marco Schiariti, Jacopo Falco, Camilla de Laurentis, Gabriella Raccuia, Paolo Ferroli, and Francesco Acerbi. 

Characterization of Ex Vivo and in Vivo Intraoperative Neurosurgical Confocal Laser Endomicroscopy Imaging." Original Research, Frontiers in Oncology 12 (2022-August-24 2022)
Xu, Yuan, Irakliy Abramov, Evgenii Belykh, Giancarlo Mignucci-Jiménez, Marian T. Park, Jennifer M. Eschbacher, and Mark C. Preul. 

November 11th, 2022 by Optiscan
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General Surgery

Near-infrared confocal imaging during mini-laparoscopy: a novel rigid endomicroscope with increased imaging plane depth', J Hepatol, 53: 84-90
Goetz, M., I. Deris, M. Vieth, E. Murr, A. Hoffman, P. Delaney, P. R. Galle, M. F. Neurath, and R. Kiesslich. 2010.

In vivo confocal laser endomicroscopy of the human liver: a novel method for assessing liver microarchitecture in real time', Endoscopy, 40: 554-62
Goetz, M., R. Kiesslich, H. P. Dienes, U. Drebber, E. Murr, A. Hoffman, S. Kanzler, P. R. Galle, P. Delaney, and M. F. Neurath. 2008. 

A Pilot Study of the Feasibility of Confocal Endomicroscopy for Examination of the Human Airway', Journal of Bronchology & Interventional Pulmonology, 17: 126-30
Musani, A. I. M., M. M. Sims, C. M. Sareli, W. R. Russell, W. J. P. McLaren, P. M. B. H. Delaney, L. A. M. Litzky and R. A. J. M. Panettieri. 2010. 

November 10th, 2022 by Optiscan
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Gastrointestinal

Prospective, double-blind diagnostic multicentre study of confocal laser endomicroscopy for wheat sensitivity in patients with irritable bowel syndrome', Gut: gutjnl-2021-325181
Bojarski, Christian, Paul Tangermann, Christian Barmeyer, Juliane Buchkremer, Ralf Kiesslich, Mark Ellrichmann, Stefan Schreiber, Carsten Schmidt, Andreas Stallmach, Robert Roehle, Christoph Loddenkemper, Severin Daum, Britta Siegmund, Michael Schumann, and Reiner Ullrich. 2021. 

In vivo endomicroscopy improves detection of Barrett's esophagus–related neoplasia: a multicenter international randomized controlled trial (with video)', Gastrointestinal Endoscopy, 79: 211-21
Canto, Marcia Irene, Sharmila Anandasabapathy, William Brugge, Gary W. Falk, Kerry B. Dunbar, Zhe Zhang, Kevin Woods, Jose Antonio Almario, Ursula Schell, John Goldblum, Anirban Maitra, Elizabeth Montgomery, and Ralf Kiesslich. 2014. 

In Vivo Confocal Endomicroscopy in the Diagnosis and Evaluation of Celiac Disease', Gastroenterology, 135: 1870-76
Leong, Rupert W. L., Nam Q. Nguyen, Christopher G. Meredith, Sam Al–Sohaily, Darko Kukic, Peter M. Delaney, Elise R. Murr, Jim Yong, Neil D. Merrett, and Andrew V. Biankin. 2008. 

Li, Wen-Bo, Xiu-Li Zuo, Chang-Qing Li, Fang Zuo, Xiao-Meng Gu, Tao Yu, Chuan-Lian Chu, Ting-Guo Zhang, and Yan-Qing Li. 2011. 'Diagnostic value of confocal laser endomicroscopy for gastric superficial cancerous lesions', Gut, 60: 299.

Mechanisms of Epithelial Cell Shedding in the Mammalian Intestine and Maintenance of Barrier Function', Annals of the New York Academy of Sciences, 1165: 135-42
Watson, Alastair J.M., Carrie A. Duckworth, Yanfang Guan, and Marshall H. Montrose. 2009. 

November 8th, 2022 by Optiscan
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Live fluorescent or antibody labelling

Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery. Molecular Imaging and Biology
Belykh, E., Jubran, J. H., George, L. L., Bardonova, L., Healey, D. R., Georges, J. F., . . . Preul, M. C. (2021). 

In vivo intravital endoscopic confocal fluorescence microscopy of normal and acutely injured rat lungs. Laboratory Investigation, 90(6), 824-834
Chagnon, F., Fournier, C., Charette, P. G., Moleski, L., Payet, M. D., Dobbs, L. G., & Lesur, O. (2010). 

Bioinspired Large Stokes Shift Small Molecular Dyes for Biomedical Fluorescence Imaging." Science Advances 8, no. 32 (2022): eabo3289
Chen, Hao, Lingjun Liu, Kun Qian, Hailong Liu, Zhiming Wang, Feng Gao, Chunrong Qu, Wenhao Dai, Daizong Lin, Kaixian Chen, Hong Liu, and Zhen Cheng. 

Assessment of nerve ultrastructure by fibre-optic confocal microscopy. 17(8), 444-448
Cushway, T. R., Lanzetta, M., Cox, G., Trickett, R., & Owen, E. R. (1996). 

In vivo visualization of GL261-luc2 mouse glioma cells by use of Alexa Fluor–labeled TRP-2 antibodies. Neurosurgical Focus, 36(2), E12
Kathryn E. Fenton, Nikolay L. Martirosyan, Mohammed G. Abdelwahab, Stephen W. Coons, Mark C. Preul, & Adrienne C. Scheck. (2014). 

Handheld confocal laser endomicroscopic imaging utilizing tumor-specific fluorescent labeling to identify experimental glioma cells in vivo. Surgical Neurology International, 7(Suppl 40), S995-S1003
Martirosyan, N. L., Georges, J., Kalani, M. Y. S., Nakaji, P., Spetzler, R. F., Feuerstein, B. G., & Preul, M. C. (2016). 

In vivo fibre optic confocal imaging of microvasculature and nerves in the rat vas deferens and colon. 192(4), 489-495
PAPWORTH, G. D., DELANEY, P. M., BUSSAU, L. J., VO, L. T., & KING, R. G. (1998).

November 6th, 2022 by Optiscan
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Intraoperative surgery and tumour margin delineation

Handheld confocal laser endomicroscopic imaging utilizing tumor-specific fluorescent labeling to identify experimental glioma cells in vivo', Surgical Neurology International, 7: S995-S1003
Martirosyan, Nikolay L., Joseph Georges, M. Yashar S. Kalani, Peter Nakaji, Robert F. Spetzler, Burt G. Feuerstein, and Mark C. Preul. 2016. 

In vivo confocal laser laparoscopy allows real time subsurface microscopy in animal models of liver disease', J Hepatol, 48: 91-7
Goetz, M., M. Vieth, S. Kanzler, P. R. Galle, P. Delaney, M. F. Neurath, and R. Kiesslich. 2008. 

Fluorescence-guided resection of tumors in mouse models of oral cancer', Scientific Reports, 10: 11175
Demétrio de Souza França, Paula, Navjot Guru, Sheryl Roberts, Susanne Kossatz, Christian Mason, Marcio Abrahão, Ronald A. Ghossein, Snehal G. Patel, and Thomas Reiner. 2020. 

Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers', Nature Biomedical Engineering, 4: 272-85
Kossatz, Susanne, Giacomo Pirovano, Paula Demétrio De Souza França, Arianna L. Strome, Sumsum P. Sunny, Daniella Karassawa Zanoni, Audrey Mauguen, Brandon Carney, Christian Brand, Veer Shah, Ravindra D. Ramanajinappa, Naveen Hedne, Praveen Birur, Smita Sihag, Ronald A. Ghossein, Mithat Gönen, Marshall Strome, Amritha Suresh, Daniela Molena, Ian Ganly, Moni A. Kuriakose, Snehal G. Patel, and Thomas Reiner. 2020. 

November 5th, 2022 by Optiscan
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Blood vessel, perfusion, and barrier function

Dynamic in vivo Imaging of Microvasculature and Perfusion by Miniaturized Confocal Laser Microscopy', European Surgical Research, 41: 290-97
Goetz, M., S. Thomas, A. Heimann, P. Delaney, C. Schneider, M. Relle, A. Schwarting, P. R. Galle, O. Kempski, M. F. Neurath, and R. Kiesslich. 2008. 

November 4th, 2022 by Optiscan
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Live microflora imaging

In Vivo Histologically Equivalent Evaluation of Gastric Mucosal Topologic Morphology in Dogs By using Confocal Endomicroscopy', Journal of Veterinary Internal Medicine, 28: 799-808
Sharman, M.J., B. Bacci, T. Whittem, and C.S. Mansfield. 2014. 

Comparison of in vivo confocal endomicroscopy with other diagnostic modalities to detect intracellular helicobacters', The Veterinary Journal, 213: 78-83
Sharman, M., B. Bacci, K. Simpson, and C. Mansfield. 2016. 

Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo', Gut, 60: 26-33
Moussata, Driffa, Martin Goetz, Annabel Gloeckner, Marcus Kerner, Barry Campbell, Arthur Hoffman, Stephan Biesterfeld, Bernard Flourie, Jean-Christophe Saurin, Peter R. Galle, Markus F. Neurath, Alastair J. M. Watson, and Ralf Kiesslich. 2011. 

November 3rd, 2022 by Optiscan
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Nano particle and drug delivery

Preparation, in vitro and in vivo evaluation of mPEG-PLGA nanoparticles co-loaded with syringopicroside and hydroxytyrosol', Journal of Materials Science: Materials in Medicine, 27: 24
Guan, Qingxia, Shuang Sun, Xiuyan Li, Shaowa Lv, Ting Xu, Jialin Sun, Wenjing Feng, Liang Zhang, and Yongji Li. 2015. 

Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging', Science Advances, 8: eabo3289
Chen, Hao, Lingjun Liu, Kun Qian, Hailong Liu, Zhiming Wang, Feng Gao, Chunrong Qu, Wenhao Dai, Daizong Lin, Kaixian Chen, Hong Liu, and Zhen Cheng. 2022. 

Virus surface-inspired ligand-switchable nanoparticles enable sequential drug delivery for improved oral insulin therapy." In.: Research Square
Yang, Tiantian, Aohua Wang, Di Nie, Weiwei Fan, Xiaohe Jiang, Miaorong Yu, Shiyan Guo, Chunliu Zhu, Gang Wei, and Yong Gan. 2022. 

Fluorescein- and EGFR-Antibody Conjugated Silica Nanoparticles for Enhancement of Real-time Tumor Border Definition Using Confocal Laser Endomicroscopy in Squamous Cell Carcinoma of the Head and Neck', Nanomaterials, 9
Watermann, Anna, Rita Gieringer, Anna-Maria Bauer, Sven Kurch, Ralf Kiesslich, Wolfgang Tremel, Jan Gosepath, and Juergen Brieger. 2019.  

November 2nd, 2022 by Optiscan
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Proof of concept in live models

Identification of Epithelial Gaps in Human Small and Large Intestine by Confocal Endomicroscopy', Gastroenterology, 133: 1769-78.
Kiesslich, Ralf, Martin Goetz, Elizabeth M. Angus, Qiuping Hu, Yanfang Guan, Chris Potten, Terry Allen, Markus F. Neurath, Noah F. Shroyer, Marshall H. Montrose, and Alastair J. M. Watson. 2007. 

In vivo intravital endoscopic confocal fluorescence microscopy of normal and acutely injured rat lungs', Laboratory Investigation, 90: 824-34.
Chagnon, Frederic, Clement Fournier, Paul G. Charette, Luc Moleski, Marcel D. Payet, Leland G. Dobbs, and Olivier Lesur. 2010. 

November 1st, 2022 by Optiscan
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